Breaking Down Migraine Treatments: erenumab vs onabotulinumtoxin – What You Need to Know.

June 17, 2025
Admin
Breaking Down Migraine Treatments: erenumab vs onabotulinumtoxin – What You Need to Know.

More than merely headaches, migraines are severe, frequently incapacitating events that can interfere with daily living. If you are among the millions impacted, you have most likely tried everything from over-the-counter medications to lifestyle adjustments. More modern therapies include Erenumab and Onabotulinumtoxin (Botox) take front stage when those choices prove inadequate.

Which one, nevertheless, would be most appropriate for you? Let’s dissect the variations, advantages, side effects, and main lessons so you may decide with knowledge.

Knowing the Foundation

Erenumab what is it?

Promoted under the Aimovig brand, Erenumab is a CGRP (calcitonin gene-related peptide) inhibitor. Involved in migraine attacks is a protein called CGRP Blocking CGRP receptors, erenumab helps to stop migraines before they start.

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FDA Certified: 2018

Applied for adult preventive treatment of migraines

What is Onabotulinumtoxin?

Some would be surprised to see onabotulinumtoxin, also known as Botox, a migraine therapy. Although most people know Botox helps to soften wrinkles, since 2010 it has been FDA-approved for use in preventing persistent migraines.

  • Form: injections once every twelve weeks.
  • FDA approved 2010 (for chronic migraines).

Designed for: 15+ headache days/month avoidance of chronic migraines

Their Mechanism

Erenumab System

Before they cause pain, erenumab inhibits migraine impulses. It aims at the CGRP receptor, therefore stopping the migraine-related pathway. This helps with both episodic and chronic migraines.

Mechanism of Onabotulinumtoxin

Botox acts differently; it inhibits nerve impulses to muscles, therefore preventing muscular contraction and lowering of migraine-related discomfort. It is injected throughout the head and neck to target particular migraine triggers.

What does the research say regarding effectiveness?

  • Both medications have demonstrated excellent success in lowering migraine days. Research studies reveal:
  • Erenumab: Monthly migraine days dropped 40 to 50%.
  • Patients who had Botox reported around 8–9 less monthly migraine days.

Your physique, type of migraine you have, and medical background will all affect your answer. For severe migraines that resist single treatment, some people even mix both therapies under physician supervision.

Side Effects: Things to Keep An Eye On

  • Most often occurring are constipation, injection site soreness, tiredness.
  • Though rare, high blood pressure and allergic responses are major concerns.

Onabotulinumtoxin

  • Most often occurring are neck stiffness, headache at the injection site, transient drooping eyelids.
  • Rare yet dangerous: trouble breathing or swallowing (particularly in cases of poison dissemination)
  • If side effects from your treatment affect your everyday life, you should talk to your healthcare professional.
  • Insurance Coverage and Cost
  • Many patients give cost a lot of weight. Roughly speaking:
  • Erenumab: About 600–700 monthly (not insured)

Botox: Every three months, each treatment session is around $1,000–$1,200.

Fortunately, many insurance policies pay for both medicines should a neurologist recommend. For eligible patients also accessible are savings cards and co-pay aid programs. Verify with your pharmacy and provider.

Out of the two, which one is best for you?

This is a basic perspective on it:

Select Erenumab in cases such as:

  • You wish for an easy at-home therapy.
  • You get episodic migraines, less than fifteen days a month.
  • You would want less trips to the clinic.
  • If you want onabotulinumtoxin and:
  • You suffer 15 or more headache days a month from chronic migraines.
  • You are cool with quarterly medical appointments.
  • You have tried other preventatives with meager results.

Based on your medical background, way of life, and treatment response, a neurologist could advise one.

Last thoughts

Though they can be life-altering, migraines do not have to be suffered in quiet. For patients experiencing regular, agonizing episodes, modern medications such as Erenumab and Onabotulinumtoxin give actual hope. The secret is discovering what suits you best and doing that under the direction of your doctor.

See a doctor and inquire about both Erenumab and Botox if you are looking at treatment choices. Maybe the game-changer you have been waiting for.

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